• Anglický jazyk

Mechanisms of Beta-cell Death in Diabetes

Autor: Fabienne Schulthess

Diabetes mellitus is a global health problem and its frequency is dramatically rising all over the world. It is a metabolic disease that is characterized by abnormally high levels of glucose in the blood. The main hormone controlling glucose metabolism is... Viac o knihe

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O knihe

Diabetes mellitus is a global health problem and its frequency is dramatically rising all over the world. It is a metabolic disease that is characterized by abnormally high levels of glucose in the blood. The main hormone controlling glucose metabolism is insulin. Insulin is released by pancreatic ß-cells in response to circulating glucose concentrations. Therefore, regulation of blood glucose is dependent on an adequate number of pancreatic ß-cells that respond appropriately to blood glucose concentrations. In diabetes this regulation fails. Autopsy studies report deficits in ß-cell mass (collective ß-cell number) ranging from 0 to 65% in type 2 diabetes and 70-100% in type 1 diabetes. Identification of the mechanism underlying this ß-cell loss is thus crucial to understand the etiology of diabetes. The results of this work elucidate important key players involved in the loss of ß-cell mass and function and postulate possible new targets for treatment.

  • Vydavateľstvo: VDM Verlag
  • Rok vydania: 2009
  • Formát: Paperback
  • Rozmer: 220 x 150 mm
  • Jazyk: Anglický jazyk
  • ISBN: 9783639207095

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