Hare, H: Progressive Medicine, Vol. 1

Excerpt from Progressive Medicine, Vol. 1: A Quarterly Digest of Advances, Discoveries and Improvements in the Medical and Surgical Sciences; March, 1912

General considerations. A discussion in extenso of the clinical syndrome must be left to the neurologist; suffice it to say that more intimate knowledge of the function of the several constituent parts of the gland must be acquired before a clear and concise clinical picture can be drawn representing various expressions of disease arising from lesions of one part of the gland or another. Of the two constituent parts, the anterior lobe is probably the most important; its secretion empties directly into the circulation, while the secretion from the posterior lobe empties into the cerebrospinal space. The latter secre tion contains certain active principles, though of much less importance to the maintenance Of the physiological equilibrium than the secretion of the anterior lobe. In general, it may be said that the various clinical manifestations are the result of hyperactivity on the one hand, and hypoactivity on the other, perversions of physiological activity similar to those observed in diseases of the thyroid gland. Hypoactivity of the hypophysis leads, as does hypoactivity of the thyroid gland, to various disturbances of development and growth. Picture the myxedematous child on the one hand, and the short, excessively fat, growing child or young adult with the stigma of undeveloped geni talia and other defects. In marked distinction to this expression of hypophyseal disease, we have the antipathy of hypoactivity in the hyperactivity of acromegaly.

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