Complex Network Models of Protein Structures

Anglický jazyk

Complex Network Models of Protein Structures

Vydavateľstvo: LAP LAMBERT Academic Publishing
Rok vydania: 2010
Formát: Paperback
Rozmer: 220 x 150 mm
Jazyk: Anglický jazyk
ISBN: 9783843358606

Na objednávku

54.63 €

bežná cena: 60.70 €

O knihe

This book presents a study of structural properties of proteins, with an exceptional finding and its correlation to folding kinetics. Proteins, with their structure-specific functions, form an important class of biomolecules for cellular functions. I used a coarse-grained graph theoretical approach, also known as complex network analysis, for my investigations. This methodology has been applied to study many complex systems ranging from social networks, technological networks (internet, WWW), transportation networks and biological networks (macromolecular, brain functional networks etc.). Interestingly, these systems with disparate origins and nature have been found to have certain common network features. In my investigations I uncovered an exceptional, generic property ("assortativity") of network models of proteins structures. I built contact networks of protein structure at different interaction-scales to identify biophysical correlate of assortativity. These findings reiterate the importance of coarse-grained models in understanding the function, kinetics of proteins. This modeling paradigm could be crucial for protein folding problem and for targeted design of enzymes.