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Anglický jazyk
Geometric, Feature- and Graph-based Analysis of Protein Structures
Autor: Thomas Fober
The structural comparison of whole proteins or protein binding sites is usually performed by making use of graphs. Even though graphs exhibit a lot of interesting and useful properties, the usage of other representations can come along with several benefits.... Viac o knihe
Na objednávku
100.51 €
bežná cena: 105.80 €
O knihe
The structural comparison of whole proteins or protein binding sites is usually performed by making use of graphs. Even though graphs exhibit a lot of interesting and useful properties, the usage of other representations can come along with several benefits. In this book the representation of a protein binding site is tackled. Three representations are considered namely the geometric, the feature-based and the graph-based representation. For all three types, some completely new algorithms are developed and presented. Moreover, existing methods are adapted to the application of protein binding sites' comparison. In addition, algorithms for the construction of multiple structural alignments are presented as a structural counterpart to multiple sequence alignment. By considering four different types of experiments, namely classification, similarity retrieval, clustering and construction of structural alignments, strengths and weaknesses of the proposed methods are detected and discussed. In addition a hybrid approach is presented which combines the benefits of a feature-based and a geometric method leading to a significant speed-up while still holding very good results.
- Vydavateľstvo: Südwestdeutscher Verlag für Hochschulschriften
- Rok vydania: 2013
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783838134796
