A Silent Threat: Exploring New Therapies for Abdominal Aortic Aneurysms

Fibronectin (FN) is a component of the interstitial ECM. It also mediates cell attachment and function [16]. It is a ¿bril-forming glycoprotein which is structurally a dimer of two identical proteins of 250 kDa covalently attached via disul¿de bonds at their C termini. It is ubiquitously expressed in tissues. Different functional motifs on its structure helps fibronectin to interact with GAGs, collagens, ¿brin and integrins facilitating matrix organization and cell¿matrix interactions [18]. For example, ¿bronectin serves as a template for proper collagen ¿brillogenesis by forming a ¿bril network engaged by cell surface integrins [16]. Cellular traction force causes FN to be stretched several times over its resting length [18]. As a result of such stretching, cryptic integrin-binding sites within the FN molecule is exposed resulting in pleiotropic changes in cellular behavior [18]. Hence FN acts as an extracellular mechano-regulator in addition to its role in cell migration during development. Studies have also shown the implication of FN in cardiovascular diseases and tumor metastasis