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Anglický jazyk
¿-Catenin, TCF, and ICAT
Autor: Mohammad Zulfiquer Hossain
In addition to working together to drive expression of target genes, ß-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood. To study the specific... Viac o knihe
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O knihe
In addition to working together to drive expression of target genes, ß-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood. To study the specific role of ß-catenin-TCF interactions in T cells, we generated transgenic mice that express ICAT, a naturally occurring inhibitor of ß-catenin-TCF interactions, in the T cell lineage. We found that ß-catenin-TCF interactions are important for thymocyte survival, but not for proliferation or differentiation. Interestingly, thymocyte aging slows down in ICAT-Tg mice, suggesting a role for ß-catenin-TCF interactions in normal thymic involution. We also discovered that ß-catenin-TCF interactions provide survival signals to activated T cells and promote differentiation of activated CD4 T cells into the default Th2 lineage. However, TCF represses Th1 differentiation independently of its interaction with ß-catenin. This study, thus, provides novel insights into the role of ß-catenin and TCF in T cell development, function, and aging, and should of interest to immunologists, developmental biologists, and gerontologists alike.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2009
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783838334509
