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Anglický jazyk
Studies on Naturally Occurring and Synthetic Quinones
Autor: C. P. Pokharna
Many synthetic as well as natural products containing the quinone functionality have displayed useful chemotherapeutic activity. Benzoyl/naphthoyl/thienoyl-1,4-benzoquinones have emerged as potential building blocks for the synthesis of medicinally significant... Viac o knihe
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O knihe
Many synthetic as well as natural products containing the quinone functionality have displayed useful chemotherapeutic activity. Benzoyl/naphthoyl/thienoyl-1,4-benzoquinones have emerged as potential building blocks for the synthesis of medicinally significant anthracyclinones. Anthracyclinones are valuable drugs in the treatment of certain human cancers. The 1,4-benzoquinones are strong electrophiles in the Diels-Alder reactions with variously substituted 1,3-butadienes. This property of quinones has been of great synthetic value.Encouraged by remarkable achievements in the field of naturally occurring as well as synthetic quinones , a systematic study of quinones including their isolation and synthesis have been undertaken. In the present study isolation of quinones from Tecomellaundulata, synthesis of rhinacanthin-A (a naphthoquinone) from lapachol and a number of benzoyl-1,4-benzoquinones were synthesized which are good precursors for the Diels-Alder reaction with various dienes and therefore, this approach may further be extended to the synthesis of anthracyclinones.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2020
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9786202530941
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