• Anglický jazyk

PHARMACOLOGICAL ACTIVITY DRIVEN SYNTHESES OF ORGANIC COMPOUNDS

Autor: Maimona Nadeem

ShorttitleThe research work reported in this book is consists of synthesis of pharmacologically active compounds and the modification of their structure according to the result of pharmacological screening. These compounds belongs to the classes 1,3,4-oxadiazole-2(3H)-thione,... Viac o knihe

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O knihe

ShorttitleThe research work reported in this book is consists of synthesis of pharmacologically active compounds and the modification of their structure according to the result of pharmacological screening. These compounds belongs to the classes 1,3,4-oxadiazole-2(3H)-thione, 1,3,4-thiadiazole-2(3H)-thione, 1,3,4-oxadiazin-4H-5(6H)-one, 4-amino-2,4-dihydro-3H-1,2,4-triazole-3-thione and 2-imidazoline. The biological activities associated with 1,3,4-oxadiazole-2(3H)-thione which initiate us to synthesize these heterocyclic compounds are discussed in chapter 1. All these compounds and some of their intermediates were screened for different biological activities including bactericidal, fungicidal, phytotoxic, cytotoxic, urease inhibitory activity and leishmanicidal activities and as expected most of them had exhibited moderate to good activities.The most important result is the evaluation of the 1,3,4-oxadiazole-2(3H)-thione, 1,3,4-thiadiazole-2(3H)-thione and 4-amino-4H-1,2,4-triazol-3-thione as potential inhibitor of the enzyme urease.

  • Vydavateľstvo: VDM Verlag
  • Rok vydania: 2009
  • Formát: Paperback
  • Rozmer: 221 x 150 mm
  • Jazyk: Anglický jazyk
  • ISBN: 9783639154849

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