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Anglický jazyk
Survey of active pharmaceutical ingredients-excipient incompatibility
Autor: Tamilvanan Shunmugaperumal
To improve physico-chemical properties of an active pharmaceutical ingredient (API) at its preformulation stage, myriad of excipients having defined functional roles like solubility enhancement by co-solvent, micells formation and complexation, intestinal... Viac o knihe
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O knihe
To improve physico-chemical properties of an active pharmaceutical ingredient (API) at its preformulation stage, myriad of excipients having defined functional roles like solubility enhancement by co-solvent, micells formation and complexation, intestinal permeability enhancement through the inhibition of efflux transport mechanisms, stability-improvement using pH adjustment, cryo-and lyo-protectants, etc are incorporated into a dosage form containing the API. Although considered primarily as inactive materials, the excipient(s) may react with the API resulting in the development of a detrimental or beneficial substance within the API-loaded dosage form itself. If detrimental substances are formed, then, the issue of API-excipient incompatibility will come up and demand the reformulation of the API, which is costly and time-consuming. This book surveys a comprehensive list of published examples of API-excipient incompatibility relevant to currently or previously marketed drugs. With this coverage, this book also provides first-hand information on the multicomponent nature and complexity of the excipients to the formulation scientist.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2010
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783843364935
