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Anglický jazyk
Brain Targeting by Intranasal Delivery
Autor: Shubhrajit Mantry
In the present day, an attempt was made to formulate and evaluate Microemulsion and Microsphere of Ropinirole Hydrochloride for better treatment of Parkinson¿s disease by improving its solubility profile and drug release of Ropinirole Hydrochloride from... Viac o knihe
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O knihe
In the present day, an attempt was made to formulate and evaluate Microemulsion and Microsphere of Ropinirole Hydrochloride for better treatment of Parkinson¿s disease by improving its solubility profile and drug release of Ropinirole Hydrochloride from its formulations in conventional buffers. It is very poorly available at the site of action for fast and immediate treatment. Thus, formulated Microemulsion and Microsphere of Ropinirole Hydrochloride avoids first pass metabolism. Microemulsion experiment was performed with Ropinirole Hydrochloride as a drug, Sesame Oil, Sunflower Oil, Castrol oil, Elainic Acid (Oleic Acid), Tween 80, Tween 20, Span 20, Span 80, Methanol, Polyethylene glycol 400, Glycerin as surfactant and co-surfactant. For the formulations F1 to F10 diffusion studies i.e. % Cumulative drug release vs. time (mins) were performed and its % cumulative drug release for all formulations was in between 83.57% to 99.93%in pH 6.6 buffer. Out of Ten formulations F2 showed the maximum % cumulative release of 99.93%. The intranasal delivered microemulsion is 0.9334±0.0292¿g/ml than the Intravenous administered PDS 0.1567±0.023 ¿g/ml.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2022
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9786204742960
