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Anglický jazyk
Chemometrics assisted spectrophotometeric determination
Autor: Yitayal Admassu Workie
Combination (consist of drugs, two or more, combined in a unique formulation) antihypertensives include combined agents from the different pharmacologic classes. More recently, a very new combination dosage form of candesartan cilexetil and hydrochlorothiazide... Viac o knihe
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O knihe
Combination (consist of drugs, two or more, combined in a unique formulation) antihypertensives include combined agents from the different pharmacologic classes. More recently, a very new combination dosage form of candesartan cilexetil and hydrochlorothiazide (from the class of angiotensin-II antagonists and diuretics) is indicated in the treatment and management hypertension. Simultaneous determination of candesartan cilexetil and hydrochlorothiazide mixtures by using spectrophotometric method is a difficult problem in analytical chemistry, due to spectral interferences. UV-spectra of studied drugs were collected from 200nm to 350nm in ethanolic solutions. In this range the studied drugs showed a considerable degree of spectral overlapping (91.82%). Initial studies of the UV-spectra of the individual compounds showed that satisfactory linear regression calibration models could be constructed in the concentration range of 5-50µg/ml and 2-20µg/ml for candesartan and hydrochlorothiazide respectively.
- Vydavateľstvo: LAP LAMBERT Academic Publishing
- Rok vydania: 2019
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9786202093453
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