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Anglický jazyk
Colon Targeted Novel Drug Delivery Systems
Autor: S. K. Uma Devi
The objective of the present study was directed towards developing a colon specific drug delivery system of aceclofenac, the non-steroidal anti-inflammatory drug associated with circadian rhythm of chronobiological symptoms for effective management of rheumatoid... Viac o knihe
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O knihe
The objective of the present study was directed towards developing a colon specific drug delivery system of aceclofenac, the non-steroidal anti-inflammatory drug associated with circadian rhythm of chronobiological symptoms for effective management of rheumatoid arthritis. Aceclofenac is a cox 2 selective inhibitor and has better safety than conventionalnon-steroidal anti-inflammatory drugs with respect to adverse effects on gastrointestinal and cardiovascular system. Aceclofenac is rapidly and completely absorbed after oral administration. Peak plasma concentration reaches in 1-3 h after an oral dose. The plasma elimination half life of the drug is approximately 4 h. The chronopharmacological approach for the management of rheumatoid arthritis has been well documented. Considering this factor, aceclofenac under investigation in the present study was developed as a colon targeted delivery system through tablets, pellets and microspheres. Additionally a Pulsincap drug delivery of the drug was also studied to meet the objective of circadian rhythm in rheumatoid arthritis.
- Vydavateľstvo: LAP Lambert Academic Publishing
- Rok vydania: 2016
- Formát: Paperback
- Rozmer: 220 x 150 mm
- Jazyk: Anglický jazyk
- ISBN: 9783659403644
