Palladium-Catalyzed C-H Functionalization, Studies Toward Ginkgolide C

Anglický jazyk

Palladium-Catalyzed C-H Functionalization, Studies Toward Ginkgolide C

Vydavateľstvo: LAP LAMBERT Academic Publishing
Rok vydania: 2012
Formát: Paperback
Rozmer: 220 x 150 mm
Jazyk: Anglický jazyk
ISBN: 9783659136276

Na objednávku, dodanie 2-4 týždne

73.17 €

bežná cena: 81.30 €

O knihe

The field of metal-catalyzed C-H bond functionalizations is an incredibly vibrant and spans beyond the formations of biaryl motifs. The mechanistic aspects of the C-H bond functionalization with metal-carboxylate complexes are highlighted. The role of additives, such as pivalic acid, is demonstrated with poorly reactive substrates. A chapter describes experimental and computational studies which suggested that a single pathway might be involved in the palladium-catalyzed C-H bond functionalization of a wide range of (hetero)arenes. Afterward a general set of conditions are developed to form biaryls by direct arylation with a wide range of heteroarenes of various complexity level. The development of two new Pd-catalyzed methods based on our knowledge on the C-H bond cleavage are apply to the formation of new scaffolds. Efforts toward the development of ligands to specifically promoted C-H bond cleavage are presented. Lastly, most recent results on the study of the mechanism of the C-H bond cleavage combining experimental and computational studies are discussed. In the second part of the thesis are presented our strategy toward the synthesis of ginkgolide C using gold catalysis.